The German designer brand has been opened in Terminal E at the AIRMALL, who runs concessions at the US airport.
The 850sq feet store features modern but classic clothing, accessories and footwear for men.
It joins Kiehl's, Montblanc and Michael Kors boutiques that took up residence in Terminal E last year, which are all operated by International Shoppes.
Michael Caro, vice president of AIRMALL Boston, says: “We are excited to add another high-fashion brand to the already robust luxury retail and duty-free offering at the AIRMALL at BOS.
"Hugo Boss offers travellers high-quality fashions and accessories, and the addition of this new store proves why the AIRMALL at BOS has become a shopping and retail destination for travellers."