A sharp year-on-year increase of 12.9% saw cargo volumes soar to 409,000 tonnes in May.
The airport also recorded a 2.5% rise in passenger numbers to six million for the month, whlile a 3% upturn in flights led to the gateway handling 35,415 aircraft movements in May.
Passenger growth in May was boosted by a 13% year-on-year increase in Hong Kong resident travel, according to airport operator, Airport Authority Hong Kong (AAHK).
It noted that routes between Hong Kong and Japan, and Hong Kong International Airport (HKIA) and Europe recorded the highest upturn in passenger traffic.
Exports continued to be the main driver behind strong cargo growth.
In May, exports recorded robust year-on-year growth of 21%. Among the key trading regions, Europe and North America increased most significantly.
During the first five months of 2017, cargo volumes at HKIA registered 11.3% year-on-year growth to 1.9 million tonnes.
Passenger throughput and flight movements increased by 1.5% to 29.8 million and 0.6% to 171,960 respectively.
On a rolling 12-month basis, HKIA handled 71 million passengers, 412,525 flight movements and 4.71 million tonnes of cargo, recording year-on-year increases of 1.5%, 0.5% and 8.5%, respectively.