Passenger numbers have been soaring at the Czech gateway since 2016 when it handled just over 13 million passengers.
The airport attributes this year's upturn in traffic to a number of new routes, rising load factors and more seats being offered on existing services.
The most popular destinations traditionally include London, Amsterdam, Moscow and Paris.
On average, approximately 49,000 passengers a day have passed through the gates of Václav Havel Airport Prague since the beginning of the year.
Throughput peaked in August when 1,997,182 passengers used the airport.
Vaclav Rehor, chair of the Prague Airport's Board of Directors, is buoyant about another good year but warns that challenges lie ahead for the gateway at it is now operating close to its design capacity.
He says: "We are celebrating another significant milestone in the airport’s history. However, this excellent result brings the airport to the very limit of its operational capacity. Further increases expected next year, may already influence passenger comfort.
"That is why it is necessary to kick-off the preparation stages of long-term airport development as soon as possible.
"Some of our development projects were already launched. In January 2020, the fourth line with new check-in counters will be open at Terminal 2 and the reconstruction of the baggage sorting centre will continue with next stage.”